Description

Atropine-D3 98 Atom % D is a high-purity, deuterium-labeled internal standard of the anticholinergic alkaloid atropine. This stable isotopically labeled compound is essential for ensuring accuracy and precision in quantitative mass spectrometry-based analyses. It is primarily utilized by pharmaceutical research and development laboratories, clinical testing facilities, and forensic science institutions for method development, validation, and routine bioanalysis.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the precise quantification of atropine and its metabolites in biological matrices (e.g., plasma, serum, urine).
• Pharmacokinetic & Toxicokinetic Studies: Enables accurate tracking of atropine absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic & Clinical Toxicology: Used in confirmatory testing for atropine or atropine-like substance poisoning, providing high specificity and reliability for legal and diagnostic purposes.
• Drug Metabolism Research: Facilitates the identification and quantification of metabolite profiles, aiding in the understanding of atropine's metabolic pathways.
• Method Development & Validation: A key reagent for developing robust analytical methods that meet regulatory standards for selectivity, accuracy, and reproducibility.
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and stability-indicating assays for atropine-containing drug products.

Basic Information

Item	Details
Product Name	Atropine-D3 98 Atom % D
CAS No.	51-54-7
Molecular Formula	C17H20D3NO3
Molecular Weight	292.40 g/mol (for D3 form)
Synonyms	Atropine-d3; (RS)-Hyoscyamine-d3; dl-Hyoscyamine-d3; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl (RS)-3-hydroxy-2-phenylpropanoate-d3; Tropine tropate-d3; Endotropine-d3; Stable Isotope Labeled Atropine; Deuterated Atropine Internal Standard
EINECS	200-104-8 (for unlabeled Atropine)

Quality Control

Every batch of Atropine-D3 98 Atom % D is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity (Atom % D), chemical purity (by HPLC), and identity confirmation (by NMR and MS). Our quality commitment ensures the material meets the stringent requirements for use in regulated bioanalytical studies under GLP and GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity (HPLC)	≥ 98%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.