Description

Quinidine Sulfate CAS NO 50-54-4 is a white to off-white crystalline powder, recognized as the sulfate salt of the alkaloid quinidine. This compound is a critical pharmaceutical active ingredient, primarily valued for its class Ia antiarrhythmic properties. It is essential for manufacturers in the pharmaceutical industry, particularly for the formulation of antiarrhythmic medications used to treat various cardiac conditions such as atrial fibrillation and flutter.

Application

• Pharmaceutical Active Ingredient: Primary use as the key component in antiarrhythmic drug formulations for cardiac rhythm management.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for drug testing and method validation.
• Biochemical Research: Used in pharmacological and electrophysiological studies to investigate ion channel (sodium and potassium) blockade mechanisms.
• Veterinary Medicine: Employed in veterinary cardiology for similar antiarrhythmic applications in animals.
• Chemical Synthesis: Acts as a chiral starting material or intermediate in the synthesis of more complex pharmaceutical compounds.

Basic Information

Product Name	Quinidine Sulfate
CAS No.	50-54-4
Molecular Formula	(C20H24N2O2)2·H2SO4·2H2O
Molecular Weight	782.96 g/mol (Dihydrate)
Synonyms	Quinidine Sulfate Dihydrate; (8S,9R)-6'-Methoxycinchonan-9-ol Sulfate; Cinchonan-9-ol, 6'-methoxy-, (8α,9R)-, sulfate (2:1) (salt), dihydrate; Pitayine Sulfate; Conchinine Sulfate; β-Quinine Sulfate; Quinidine Sulphate; Quinidine Bisulfate
EINECS	200-056-1

Quality Control

Our Quinidine Sulfate is manufactured under strict quality systems. It is typically tested for compliance with major pharmacopoeial standards such as USP and EP. Each batch undergoes rigorous analytical testing including assay, impurity profiling, and identification. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; appropriate handling is required to maintain stability and potency.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms
Identification (TLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Rotation	+275° to +290° (c = 2 in 0.1M HCl)
pH (1% solution)	6.0 - 7.0
Water (KF)	4.0% - 6.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.