Description

(E)-Ethyl 3-Amino-4,4,4-Trifluorocrotonate is a high-value fluorinated organic building block characterized by its amino and ester functional groups. This compound is essential for the synthesis of complex molecules, particularly in the development of novel pharmaceuticals and agrochemicals where the trifluoromethyl group imparts enhanced metabolic stability and bioavailability. It is primarily sought after by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), especially in the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Fluorinated Building Block: Serves as a versatile precursor in organic synthesis for introducing the 3-amino-4,4,4-trifluorobut-2-enoate moiety into more complex molecular architectures.
• Material Science Research: Employed in the research and development of fluorinated polymers or specialty chemicals with unique surface properties.
• Chemical Biology Probes: Useful in the design and synthesis of molecular probes and tags for studying biological systems.

Basic Information

Product Name	(E)-Ethyl 3-Amino-4,4,4-Trifluorocrotonate
CAS No.	498583-09-8
Molecular Formula	C6H8F3NO2
Molecular Weight	183.13 g/mol
Synonyms	Ethyl (2E)-3-amino-4,4,4-trifluorobut-2-enoate; (E)-Ethyl 3-amino-4,4,4-trifluorobut-2-enoate; 3-Amino-4,4,4-trifluorocrotonic Acid Ethyl Ester; Ethyl 3-Amino-4,4,4-trifluorocrotonate; ATFC; 4,4,4-Trifluoro-3-aminocrotonic Acid Ethyl Ester; (E)-3-Amino-4,4,4-trifluorobut-2-enoic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our (E)-Ethyl 3-Amino-4,4,4-Trifluorocrotonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is sensitive to strong alkali and fluorides; keep away from incompatible substances. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.