Description

[(1R,2R,3S)-(+)-1,2-Dimethyl-2,3-Bis(Diphenylphosphinomethyl)Cyclopentyl]Methanol is a high-value, chiral diphosphine ligand derivative, prized for its ability to induce stereoselectivity in catalytic transformations. Its core value lies in providing exceptional enantiocontrol in asymmetric synthesis, a critical factor for producing high-purity active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance chiral auxiliaries.

Application

• Asymmetric Hydrogenation Catalysis: As a key ligand precursor for transition metal complexes (e.g., Rh, Ru, Ir) used in the enantioselective hydrogenation of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer intermediates for chiral drugs, including β-blockers, antivirals, and anti-inflammatory agents.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and pesticides to enhance efficacy and reduce environmental impact.
• Cross-Coupling Reactions: Serves as a chiral ligand in asymmetric cross-coupling reactions (e.g., Suzuki, Heck) to construct complex chiral biaryl structures.
• Hydroformylation and Hydroamination: Applied in metal-catalyzed asymmetric hydroformylation of alkenes and hydroamination of alkenes/alkynes.
• Academic and Industrial R&D: A vital tool for developing new catalytic methodologies and exploring novel reaction pathways in process chemistry.

Basic Information

Product Name	[(1R,2R,3S)-(+)-1,2-Dimethyl-2,3-Bis(Diphenylphosphinomethyl)Cyclopentyl]Methanol
CAS No.	497262-02-9
Molecular Formula	C35H40O1P2
Molecular Weight	538.65 g/mol
Synonyms	(1R,2R,3S)-(+)-1,2-Dimethyl-2,3-bis(diphenylphosphanylmethyl)cyclopentylmethanol; (1R,2R,3S)-1,2-Dimethyl-2,3-bis[(diphenylphosphino)methyl]cyclopentanemethanol; (+)-DIMOP; (R,R,S)-DIMOP; DIMOP Ligand; (1R,2R,3S)-DIMOP; (1R,2R,3S)-(+)-DIMOP; Cyclopentanemethanol, 1,2-dimethyl-2,3-bis[(diphenylphosphino)methyl]-, (1R,2R,3S)-
EINECS	Contact for details

Quality Control

Our [(1R,2R,3S)-(+)-1,2-Dimethyl-2,3-Bis(Diphenylphosphinomethyl)Cyclopentyl]Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and specific rotation measurement to ensure identity, potency, and enantiomeric excess meet stringent specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.