Description

n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-2-(4-Methoxybenzyl)-β-Alanine is a specialized Fmoc-protected amino acid derivative, a critical building block in modern solid-phase peptide synthesis (SPPS). Its value lies in enabling the precise and efficient construction of complex peptide sequences, particularly those requiring the incorporation of a modified β-alanine residue with a 4-methoxybenzyl (PMB) protecting group. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated, stepwise assembly of custom peptide chains.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs, hormones, and enzyme inhibitors.
• Bioconjugation: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carriers.
• Combinatorial Chemistry: A valuable building block for creating libraries of peptide analogs for high-throughput screening.
• Academic & Industrial R&D: Fundamental reagent for studying protein structure-function relationships and peptide biochemistry.
• Production of Modified Peptides: Specifically enables the introduction of a β-alanine residue with an orthogonal PMB-protected side chain, allowing for selective deprotection and further functionalization.

Basic Information

Product Name	n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-2-(4-Methoxybenzyl)-β-Alanine
CAS No.	497059-62-8
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-β-Ala(4-MeOBzl)-OH; Fmoc-3-amino-3-(4-methoxyphenyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(4-methoxyphenyl)-β-alanine; Fmoc-β-(4-methoxybenzyl)-Ala-OH; N-Fmoc-2-(4-methoxybenzyl)-β-alanine; Fmoc-Pmb-β-Ala-OH; 3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(4-methoxyphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-2-(4-Methoxybenzyl)-β-Alanine is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral purity checks where applicable, to ensure it meets the exacting standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and consistency for your critical research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive); containers should be sealed under inert atmosphere after opening to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.