Description

5-Trifluoromethyl-1H-Indole-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block characterized by its indole core and trifluoromethyl substituent. This compound matters for its critical role in modern pharmaceutical and agrochemical research, where it serves as a key precursor for synthesizing novel active ingredients. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate its unique fluorine-containing scaffold into new molecular entities.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers, organic semiconductors, and liquid crystals with tailored electronic properties.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or linker in the design of chemical probes, enzyme inhibitors, and activity-based protein profiling reagents.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting fundamental research in synthetic organic and medicinal chemistry.

Basic Information

Product Name	5-Trifluoromethyl-1H-Indole-2-Carboxylic Acid
CAS No.	496946-78-2
Molecular Formula	C10H6F3NO2
Molecular Weight	229.16 g/mol
Synonyms	5-(Trifluoromethyl)-1H-indole-2-carboxylic acid; 2-Carboxy-5-(trifluoromethyl)indole; 5-Trifluoromethylindole-2-carboxylic acid; 1H-Indole-2-carboxylic acid, 5-(trifluoromethyl)-; 5-Trifluoromethyl-1H-indole-2-carboxylic acid; 5-CF3-1H-Indole-2-carboxylic acid; 5-Trifluoromethylindole-2-carboxylic acid; 5-Trifluoromethyl-2-indolecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethyl-1H-Indole-2-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.