Description

n-Boc-4-Cyanopiperidine-4-Carboxylic Acid, also known as 1-(tert-Butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid, is a high-purity, multifunctional piperidine derivative of significant importance in advanced organic synthesis. This compound serves as a critical building block for medicinal chemistry, enabling the rapid construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Peptidomimetic Chemistry: Used to incorporate constrained, functionalized piperidine scaffolds into peptide backbones to modulate biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Agrochemical Research: Acts as an intermediate in the development of new herbicides and pesticides with novel modes of action.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	n-Boc-4-Cyanopiperidine-4-Carboxylic Acid
CAS No.	495415-34-4
Molecular Formula	C12H18N2O4
Molecular Weight	254.28 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid; 4-Cyano-1-Boc-piperidine-4-carboxylic acid; 1-Boc-4-cyanoisonipecotic acid; 4-Cyano-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic acid; tert-Butyl 4-cyano-4-carboxypiperidine-1-carboxylate; 4-Cyano-1-N-Boc-piperidine-4-carboxylic acid; Piperidine-4-carboxylic acid, 4-cyano-1-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our n-Boc-4-Cyanopiperidine-4-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP compliance for pharmaceutical development, and we can accommodate custom purity specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.