Description

γ-Glutamine-13C,15N Hydrochloride is a high-purity, isotopically labeled derivative of the amino acid glutamine, specifically designed for advanced research and analytical applications. This compound is essential for metabolic pathway tracing, protein turnover studies, and quantitative mass spectrometry due to its stable carbon-13 and nitrogen-15 isotopes. It is primarily utilized by research institutions, pharmaceutical developers, and CROs engaged in proteomics, metabolomics, and pharmacokinetic research.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to study glutamine metabolism in cell cultures and model organisms.
• Quantitative Proteomics: Serves as an internal standard for the accurate quantification of glutamine-containing peptides and proteins via mass spectrometry.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in isotope dilution methods to track the absorption, distribution, metabolism, and excretion of pharmaceutical compounds.
• NMR Spectroscopy: Provides a non-radioactive, stable isotopic label for structural and dynamic studies of biomolecules.
• Nutritional Research: Used to investigate glutamine utilization, requirements, and turnover in nutritional studies.
• Biochemical Pathway Elucidation: Aids in mapping and validating specific biochemical pathways involving glutamine.

Basic Information

Product Name	γ-Glutamine-13C,15N Hydrochloride
CAS No.	494783-18-5
Molecular Formula	C413CH915N2O3 • HCl
Molecular Weight	183.59 g/mol (for 13C5, 15N2)
Synonyms	L-Glutamine-13C5,15N2 hydrochloride; (2S)-2-Amino-4-carbamoyl-13C5,15N2butanoic acid hydrochloride; Glutamine-13C5,15N2 HCl; Isotopically labeled L-glutamine HCl; L-Gln-13C5,15N2 hydrochloride; Stable isotope-labeled glutamine hydrochloride
EINECS	Contact for details

Quality Control

Our γ-Glutamine-13C,15N Hydrochloride is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity confirmation. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom %
Isotopic Enrichment (15N)	≥ 99 atom %
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.