Description

(S)-1-Dicyclohexylphosphino-2-[(R)- -(Dimethylamino)-2-(Dicyclohexylphosph is a highly specialized, chiral phosphine ligand critical for enabling precise stereoselective control in advanced catalytic transformations. Its value lies in its ability to direct the formation of specific enantiomers, which is paramount for producing high-value, optically pure compounds in pharmaceutical and fine chemical synthesis. This product is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require robust and selective catalysts for asymmetric hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral intermediates for active pharmaceutical ingredients (APIs).
• Cross-Coupling Reactions: Facilitates stereoselective C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations, with high enantiomeric excess.
• Pharmaceutical Intermediate Synthesis: Used in the development and scale-up of chiral drugs, including those for cardiovascular, central nervous system, and oncological therapies.
• Agrochemical Production: Enables the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic and Industrial R&D: A valuable tool for methodology development in organic synthesis and catalyst discovery within research laboratories.
• Fine Chemical Manufacturing: Applied in the production of specialty flavors, fragrances, and advanced materials requiring specific chirality.

Basic Information

Product Name	(S)-1-Dicyclohexylphosphino-2-[(R)- -(Dimethylamino)-2-(Dicyclohexylphosph
CAS No.	494227-38-2
Molecular Formula	C26H49NP2
Molecular Weight	437.62 g/mol
Synonyms	(R)-(+)-2-(Dicyclohexylphosphino)-2'-(dimethylamino)-1,1'-binaphthyl; (R)-DM-BINAP; Josiphos SL-J009-1 type ligand; (R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldicyclohexylphosphine (common misassignment for related ferrocenyl ligands); (R)-N,N-Dimethyl-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethylamine (IUPAC-style for core structure); Chiral Josiphos-type ligand; Asymmetric bidentate phosphine ligand.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) are provided, detailing key parameters such as enantiomeric excess (ee), assay, and impurity profiles. We adhere to strict internal quality protocols to ensure batch-to-batch consistency and reliability for your critical catalytic applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. Due to its sensitivity to oxidation, the container should only be opened in a controlled, oxygen-free environment. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.