Description

(Alphar,Alphar)-1,1'-Bis[α-(Dimethylamino)Benzyl]-(S,S)-2,2'-Bis(Dicyclohexylphosphino)Ferrocene CAS NO 494227-35-9 is a highly specialized, chiral ferrocenyl phosphine ligand designed for asymmetric catalysis. This compound matters for its exceptional ability to induce high enantioselectivity in a variety of transition-metal-catalyzed reactions, enabling the production of single-enantiomer intermediates crucial for advanced pharmaceuticals and fine chemicals. It is primarily needed by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, a key step in synthesizing chiral active pharmaceutical ingredients (APIs).
• Asymmetric C-C Bond Formation: Catalyzes cross-coupling and addition reactions, such as Suzuki-Miyaura and Heck reactions, with high stereocontrol for constructing complex molecular architectures.
• Pharmaceutical Intermediate Synthesis: Critical for the production of enantiomerically pure intermediates used in cardiovascular, central nervous system (CNS), and antiviral drug candidates.
• Agrochemical Production: Used in the synthesis of chiral herbicides, fungicides, and pesticides where biological activity is often enantiomer-specific.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new asymmetric transformations in academic laboratories and corporate R&D centers.
• Process Chemistry Optimization: Employed to develop scalable, efficient, and cost-effective catalytic processes for commercial-scale manufacturing.

Basic Information

Product Name	(Alphar,Alphar)-1,1'-Bis[α-(Dimethylamino)Benzyl]-(S,S)-2,2'-Bis(Dicyclohexylphosphino)Ferrocene
CAS No.	494227-35-9
Molecular Formula	C54H74FeN2P2
Molecular Weight	853.00 g/mol
Synonyms	(S,S)-Alphar-Ferrocene; (S,S)-Alphar-Fc; (S,S)-Alphar-Ferrocenyl Phosphine Ligand; (S,S)-1,1'-Bis[α-(Dimethylamino)benzyl]-2,2'-bis(dicyclohexylphosphino)ferrocene; (S,S)-Alphar-Ferrocene Ligand; Josiphos-type Ligand Derivative; Chiral Ferrocenyl Diphosphine; (S,S)-Alphar
EINECS	Contact for details

Quality Control

Our (Alphar,Alphar)-1,1'-Bis[α-(Dimethylamino)Benzyl]-(S,S)-2,2'-Bis(Dicyclohexylphosphino)Ferrocene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light may lead to decomposition and reduced catalytic activity.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Moisture Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.