Description

(R)-1-[(R)-2-[2-[Di(3,5-Xylyl)Phosphino]Phenyl]Ferrocenyl]Ethyldi(3,5-Xylyl)Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in advanced asymmetric catalysis. Its value lies in its ability to impart exceptional enantioselectivity and high catalytic activity in critical carbon-carbon and carbon-heteroatom bond-forming reactions. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for synthesizing chiral active pharmaceutical ingredients (APIs) and other high-value intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines, crucial for producing single-enantiomer pharmaceutical building blocks.
• Asymmetric C-C Bond Formation: Employed in cross-coupling reactions, allylic substitutions, and other transition-metal catalyzed processes to construct chiral centers with high fidelity.
• Pharmaceutical Intermediate Synthesis: Key catalyst component in the synthesis of chiral drugs for therapeutic areas such as oncology, cardiology, and central nervous system disorders.
• Agrochemical Production: Used to create enantiomerically pure herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profiles.
• Fine Chemical and Fragrance Manufacturing: Enables the production of high-value chiral flavors, fragrances, and specialty materials.
• Academic and Process R&D: A vital tool for methodology development and scaling up novel asymmetric synthetic routes in research laboratories.

Basic Information

Product Name	(R)-1-[(R)-2-[2-[Di(3,5-Xylyl)Phosphino]Phenyl]Ferrocenyl]Ethyldi(3,5-Xylyl)Phosphine
CAS No.	494227-33-7
Molecular Formula	C58H56FeP2
Molecular Weight	870.81 g/mol
Synonyms	(R,R)-JOSIPHOS SL-J009-1; (R)-1-[(R)-2-(2-(Di(3,5-xylyl)phosphino)phenyl)ferrocenyl]ethyldi(3,5-xylyl)phosphine; Josiphos SL-J009-1; (R,R)-JOSIPHOS ligand SL-J009-1; (R,R)-JOSIPHOS-type ligand; (R,R)-1-[(R)-2-[2-(Bis(3,5-dimethylphenyl)phosphino)phenyl]ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine; (R,R)-1-[(R)-2-[2-(Di(3,5-xylyl)phosphino)phenyl]ferrocenyl]ethyldi(3,5-xylyl)phosphine
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is manufactured and tested under strict quality management protocols to ensure exceptional purity and performance consistency for catalytic applications. Identity and purity are verified by advanced analytical techniques including NMR (¹H, ³¹P), HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and relevant physical data is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and moisture-sensitive; handling should be performed in a controlled, dry environment using appropriate inert techniques.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.