Description

(R)-1-[(R)-2-[2-(Dicyclohexylphosphino)Phenyl]Ferrocenyl]Ethylbis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce exceptional enantioselectivity and high catalytic activity in a range of transition-metal-catalyzed reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who are developing novel synthetic routes for chiral molecules.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for producing single-enantiomer pharmaceutical intermediates.
• Asymmetric Cross-Coupling Reactions: Facilitates C-C and C-X bond-forming reactions with high stereocontrol, such as Suzuki-Miyaura and Buchwald-Hartwig aminations.
• Pharmaceutical Intermediate Synthesis: Enables the efficient, scalable production of chiral active pharmaceutical ingredients (APIs) and key building blocks.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Process R&D: A valuable tool for methodology development and optimizing catalytic processes in research laboratories.
• Fine Chemical Manufacturing: Applied in the synthesis of complex, high-value specialty chemicals, flavors, and fragrances requiring precise stereochemistry.

Basic Information

Product Name	(R)-1-[(R)-2-[2-(Dicyclohexylphosphino)Phenyl]Ferrocenyl]Ethylbis[3,5-Bis(Trifluoromethyl)Phenyl]Phosphine
CAS No.	494227-32-6
Molecular Formula	C51H49F12FeP2
Molecular Weight	992.68 g/mol
Synonyms	(R)-1-[(R)-2-(2-Dicyclohexylphosphinophenyl)ferrocenyl]ethyldi(3,5-bis(trifluoromethyl)phenyl)phosphine; Josiphos SL-J009-1; (R)-(S)-Josiphos (SL-J009-1); (R)-1-[(S)-2-(2-Dicyclohexylphosphino-phenyl)ferrocenyl]ethyl-di(3,5-bis-trifluoromethyl-phenyl)phosphine; (R)-1-[(S)-2-[2-(Dicyclohexylphosphino)phenyl]ferrocenyl]ethylbis[3,5-bis(trifluoromethyl)phenyl]phosphine; SL-J009-1; JosiPhos Ligand SL-J009-1
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity chiral ligands. Every batch is characterized by NMR (1H, 31P, 19F) and HPLC to confirm identity, enantiomeric excess, and purity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. Allow the container to reach room temperature in a dry environment before opening to minimize moisture exposure.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.