Description

(R)-1-[(R)-2-[2-(Diphenylphosphino)Phenyl]Ferrocenyl]Ethyldi(3,5-Xylyl)Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in advanced asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, crucial for producing single-isomer pharmaceutical intermediates and fine chemicals with superior purity and yield. This ligand is essential for R&D scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control in hydrogenation, cross-coupling, and other transition metal-catalyzed reactions.

Application

• As a chiral ligand for asymmetric hydrogenation of prochiral olefins, ketones, and imines in pharmaceutical API synthesis.
• Catalyst component for enantioselective cross-coupling reactions (e.g., Suzuki-Miyaura, Heck) to construct chiral biaryl systems.
• Key reagent in the development of stereoselective synthetic routes for complex natural products and agrochemicals.
• Use in academic and industrial R&D for discovering new catalytic asymmetric methodologies.
• Precursor for immobilized catalyst systems used in continuous flow chemistry applications.
• Critical for manufacturing optically pure intermediates for chiral drugs, including antivirals, anticancer agents, and cardiovascular therapies.

Basic Information

Product Name	(R)-1-[(R)-2-[2-(Diphenylphosphino)Phenyl]Ferrocenyl]Ethyldi(3,5-Xylyl)Phosphine
CAS No.	494227-31-5
Molecular Formula	C51H48FeP2
Molecular Weight	778.68 g/mol
Synonyms	(R,R)-JOSIPHOS SL-J009-1; (R)-1-[(R)-2-[2-(Diphenylphosphino)phenyl]ferrocenyl]ethyldi(3,5-xylyl)phosphine; Josiphos SL-J009-1; (R,R)-JOSIPHOS ligand SL-J009-1; (R,R)-SL-J009-1; (R)-1-[(R)-2-(2-Diphenylphosphinophenyl)ferrocenyl]ethyldi(3,5-dimethylphenyl)phosphine; (R,R)-1-[(R)-2-[2-(Diphenylphosphino)phenyl]ferrocenyl]ethyldi(3,5-xylyl)phosphine
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management to ensure exceptional purity and enantiomeric excess, critical for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as chiral purity (by HPLC), elemental analysis, and spectroscopic identity (NMR). Our production adheres to cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and ensure long-term stability. Allow the container to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.