Description

3-Chloro-5-Fluorophenylacetonitrile is a versatile and high-purity fluorinated aromatic nitrile building block. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique halogenated structure enables the introduction of key functional groups. It is primarily sought after by research institutions and industrial manufacturers developing active pharmaceutical ingredients (APIs), advanced agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel drug candidates, particularly for CNS-targeted therapies and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine and chlorine substituents for enhanced bioactivity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties.
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl systems.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic pathways and creating specialized chemical libraries.
• Dye & Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	3-Chloro-5-Fluorophenylacetonitrile
CAS No.	493038-93-0
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	(3-Chloro-5-fluorophenyl)acetonitrile; 2-(3-Chloro-5-fluorophenyl)acetonitrile; 3-Chloro-5-fluorobenzeneacetonitrile; 3-Chloro-5-fluoro-benzeneacetonitrile; α-(3-Chloro-5-fluorophenyl)acetonitrile; 3-Chloro-5-fluoro phenylacetonitrile
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluorophenylacetonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive quality assurance, with each lot supported by a detailed Certificate of Analysis (COA) that includes results from HPLC, GC, NMR, and other relevant analytical techniques. Our quality control protocols are designed to meet the stringent requirements of pharmaceutical and advanced material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.