Description

2,6-Difluoro-4-(trifluoromethyl)benzyl bromide is a high-value, multi-fluorinated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and bromine substituents, makes it an essential reagent for introducing the 2,6-difluoro-4-(trifluoromethyl)benzyl moiety into target molecules, enabling precise modulation of electronic properties, lipophilicity, and metabolic stability. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drugs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides where the difluoro-trifluoromethylbenzyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic compounds for electronic materials, improving charge transport and stability in display technologies.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to construct complex biaryl systems.
• Ligand & Catalyst Development: Employed in the synthesis of specialized fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine-18 Radiochemistry: Potential precursor for the synthesis of PET (Positron Emission Tomography) tracers, leveraging its fluorine atoms for isotopic labeling.

Basic Information

Product Name	2,6-Difluoro-4-(trifluoromethyl)benzyl bromide
CAS No.	493038-91-8
Molecular Formula	C9H4BrF5
Molecular Weight	287.03 g/mol
Synonyms	α-Bromo-2,6-difluoro-α,α,α-trifluoro-p-xylene; 2,6-Difluoro-α-(bromomethyl)-α,α,α-trifluorotoluene; (2,6-Difluoro-4-(trifluoromethyl)phenyl)methyl bromide; 4-(Bromomethyl)-3,5-difluorobenzotrifluoride; 1-(Bromomethyl)-2,6-difluoro-4-(trifluoromethyl)benzene; 2,6-Difluoro-4-trifluoromethylbenzyl bromide; DFB-TFMB-Br
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-4-(trifluoromethyl)benzyl bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to strong acids and organic solvents, keep away from incompatible materials. Handle and store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.