Description

Dihydronormorphine 3-β-D-Glucuronide is a key glucuronide metabolite of dihydronormorphine, a compound of significant interest in pharmacological research. This reference standard is critical for analytical method development and validation in forensic and clinical toxicology laboratories. It is primarily utilized by researchers and quality control professionals in the pharmaceutical, forensic science, and diagnostic industries for precise metabolite identification and quantification.

Application

• Reference Standard for Analytical Testing: Used as a primary standard in HPLC, LC-MS/MS, and GC-MS methods for the accurate quantification of opioid metabolites.
• Forensic Toxicology Research: Essential for developing and validating assays to detect and confirm opioid use in biological samples (e.g., urine, blood).
• Pharmacokinetic and Metabolism Studies: Employed in research to understand the metabolic pathways, clearance rates, and bioavailability of dihydronormorphine and related opioids.
• Clinical Laboratory Testing: Serves as a calibrator or control material in diagnostic tests for monitoring drug therapy compliance or substance abuse.
• Pharmaceutical Impurity Profiling: Used to identify and quantify potential glucuronidated impurities or degradation products in active pharmaceutical ingredient (API) batches.
• Biochemical Research: Applied in studies investigating the activity and inhibition of UDP-glucuronosyltransferase (UGT) enzymes.

Basic Information

Product Name	Dihydronormorphine 3-β-D-Glucuronide
CAS No.	491847-30-4
Molecular Formula	C23H29NO9
Molecular Weight	463.48 g/mol
Synonyms	Dihydronormorphine 3-Glucuronide; Normorphine-3-glucuronide, dihydro-; 3-β-D-Glucopyranuronosyl-dihydronormorphine; Dihydronormorphine 3-β-D-glucopyranosiduronic acid; Dihydro-normorphine-3-glucuronide; 4,5α-Epoxy-3-hydroxy-17-methylmorphinan-6-one 3-β-D-glucuronide (dihydro derivative); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Dihydronormorphine 3-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity assay and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥95.0% (Area Percent)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.