Description

Eliglustat CAS NO 491833-29-5 is a potent and selective glucosylceramide synthase inhibitor, representing a significant advancement in targeted substrate reduction therapy. Its primary value lies in its ability to specifically reduce the accumulation of glucosylceramide, a key substrate for the synthesis of complex glycosphingolipids. This makes it a critical active pharmaceutical ingredient (API) for the treatment of Gaucher disease type 1, a lysosomal storage disorder. Pharmaceutical manufacturers and research institutions engaged in developing and producing oral therapeutics for metabolic diseases are the primary users of this high-purity compound.

Application

• Primary use as the Active Pharmaceutical Ingredient (API) in the formulation of oral capsules for the treatment of Gaucher disease type 1.
• Key component in clinical research and development of new therapeutic agents targeting glycosphingolipid metabolism.
• Used as a reference standard in analytical laboratories for quality control and method development of related pharmaceutical products.
• Valuable pharmacological research tool for studying the biochemical pathways of sphingolipid synthesis and related disorders.
• Potential use in combination therapy studies for lysosomal storage diseases.

Basic Information

Product Name	Eliglustat
CAS No.	491833-29-5
Molecular Formula	C23H36N2O4
Molecular Weight	404.55 g/mol
Synonyms	Genz-112638; (1R,2R)-Octanoic acid [1-(2,3-dihydroxy-propoxy)-1-(2,3-dihydroxy-propylcarbamoyl)-2-pentyl-cyclopentyl]-amide; N-[(1R,2R)-1-(2,3-Dihydroxypropoxy)-1-(hydroxymethyl)-2-pentylcyclopentyl]octanamide; Eliglustat tartrate (salt form precursor); GCS inhibitor; Glucosylceramide synthase inhibitor; Cerdelga (brand name API).
EINECS	Contact for details

Quality Control

Our Eliglustat is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical development and use. Quality is assured through comprehensive analytical testing, including identity confirmation, purity assessment, and impurity profiling. We provide full traceability and support regulatory submissions. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting compliance with agreed-upon specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity: ≤0.5% Total impurities: ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.