Description

2-Iodo-4-Methoxybenzonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both an electron-donating methoxy group and an electron-withdrawing nitrile, makes it a valuable precursor for constructing complex heterocycles and functionalized aromatic systems. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of potential drug candidates, particularly for constructing complex heterocyclic cores found in various therapeutic agents.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogen and nitrile functionalities for bioactivity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal-catalyzed cross-coupling reactions, such as Suzuki and Sonogashira couplings.
• Material Science: Employed in the research and synthesis of advanced organic electronic materials, liquid crystals, and polymers where its specific substitution pattern can tune electronic properties.
• Chemical Biology & Probe Synthesis: Useful for creating molecular probes and tags due to the reactivity of the iodine atom for further functionalization via halogen exchange or cross-coupling.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, enabling new routes for C-C and C-N bond formation.

Basic Information

Product Name	2-Iodo-4-Methoxybenzonitrile
CAS No.	490039-83-3
Molecular Formula	C8H6INO
Molecular Weight	259.05 g/mol
Synonyms	4-Methoxy-2-iodobenzonitrile; 2-Iodo-4-methoxybenzonitrile; 4-Methoxy-2-iodobenzene carbonitrile; 2-Cyano-5-iodoanisole; Benzonitrile, 2-iodo-4-methoxy-; 490039-83-3
EINECS	Contact for details

Quality Control

Our 2-Iodo-4-Methoxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.