Description

2-Iodo-3-Methoxybenzonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both an iodine substituent and a methoxy group ortho to a nitrile, makes it a valuable precursor for constructing complex molecules via cross-coupling reactions and functional group transformations. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with unique modes of action.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Material Science Precursor: Employed in the synthesis of organic electronic materials, such as charge-transport molecules or liquid crystals.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings to create biaryl and other complex structures.
• Functional Group Transformation: The nitrile group can be hydrolyzed to carboxylic acids, reduced to amines, or converted into tetrazoles, expanding its utility in scaffold diversification.

Basic Information

Product Name	2-Iodo-3-Methoxybenzonitrile
CAS No.	490039-70-8
Molecular Formula	C8H6INO
Molecular Weight	259.05 g/mol
Synonyms	3-Methoxy-2-iodobenzonitrile; 2-Iodo-3-methoxybenzonitrile; Benzonitrile, 2-iodo-3-methoxy-; 2-Iodo-m-anisonitrile; 2-Cyano-6-iodoanisole; 6-Iodo-2-methoxybenzonitrile; 2-Methoxy-6-iodobenzonitrile
EINECS	Contact for details

Quality Control

Our 2-Iodo-3-Methoxybenzonitrile is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization and purity verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, assay, and impurity profiles to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.