Description

3-(Acetyloxy)-5-Iodophenol-2’,3’,4’-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester is a sophisticated synthetic intermediate, specifically a protected glucuronide derivative, designed for advanced pharmaceutical research and development. This compound is critical for scientists working on prodrug synthesis and metabolic studies, where controlled conjugation and deconjugation are essential. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical and biotechnology sectors for creating targeted therapeutics and conducting crucial ADME (Absorption, Distribution, Metabolism, and Excretion) profiling.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel prodrug candidates designed for targeted drug delivery and enhanced bioavailability.
• Metabolite Synthesis: Used as a precursor for generating reference standards of drug metabolites, essential for accurate analytical method development and validation in bioanalysis.
• Glycoconjugate Research: Serves as a protected substrate in studies exploring enzymatic glucuronidation pathways and the synthesis of complex carbohydrate-based molecules.
• Chemical Biology Probes: Employed in the development of molecular probes to study enzyme activity, particularly glucuronidases and esterases, within biological systems.
• Process Chemistry: Utilized in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs) requiring glucuronide functionality.

Basic Information

Product Name	3-(Acetyloxy)-5-Iodophenol-2’,3’,4’-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester
CAS No.	490028-21-2
Molecular Formula	C₂₀H₂₁IO₁₂
Molecular Weight	604.27 g/mol
Synonyms	Methyl (2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-((5-acetoxy-3-iodophenoxy)acetoxy)tetrahydro-2H-pyran-2-carboxylate; 5-Iodo-3-acetoxyphenyl 2,3,4-Tri-O-acetyl-β-D-glucopyranosiduronic Acid Methyl Ester; Protected 5-Iodosalicylic Acid Glucuronide Methyl Ester; 3-Acetoxy-5-iodophenyl β-D-glucuronide methyl ester peracetate; 490028-21-2; 3-Acetyloxy-5-iodophenol glucuronide methyl ester triacetate
EINECS	Contact for details

Quality Control

Every batch of 3-(Acetyloxy)-5-Iodophenol-2’,3’,4’-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by NMR and/or IR), and impurity profiles is provided with each shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.