Description

5-Iodoresorcinol-2’,3’,4’-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester is a sophisticated synthetic intermediate, specifically a protected glucuronide derivative. This compound is of significant value in advanced pharmaceutical research and development, particularly in the synthesis of drug metabolites and prodrugs. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in drug discovery, ADME (Absorption, Distribution, Metabolism, and Excretion) studies, and analytical method development.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of complex drug metabolites and glucuronide conjugates for pharmacological studies.
• Reference Standard: Serves as a high-purity analytical standard in HPLC and LC-MS methods for quantifying drug metabolites in biological matrices.
• Prodrug Development: Used in research to design and synthesize prodrugs that utilize glucuronidation for targeted drug delivery or improved bioavailability.
• Bioconjugation Chemistry: Acts as a specialized reagent in the development of antibody-drug conjugates (ADCs) or other targeted therapies where a glucuronide linker is required.
• Enzymology Research: Employed as a substrate for studying the activity and kinetics of UDP-glucuronosyltransferase (UGT) enzymes.
• Chemical Biology Probes: Utilized in the creation of molecular probes to investigate glycosylation pathways and cellular processes.

Basic Information

Product Name	5-Iodoresorcinol-2’,3’,4’-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester
CAS No.	490028-20-1
Molecular Formula	C18H19IO11
Molecular Weight	538.24 g/mol
Synonyms	Methyl (2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-((5-iodo-2,4-dihydroxyphenoxy)tetrahydro-2H-pyran-2-carboxylate; 5-Iodoresorcinol Glucuronide Methyl Ester Triacetate; β-D-Glucopyranuronic acid, methyl 1-[(5-iodo-2,4-dihydroxyphenyl)]-, 2,3,4-triacetate; Protected 5-Iodoresorcinol Glucuronide; 5-Iodoresorcinol-2,3,4-tri-O-acetyl-β-D-glucuronide methyl ester; Triacetylated 5-Iodoresorcinol Glucuronide Methyl Ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of 5-Iodoresorcinol-2’,3’,4’-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester is characterized and verified using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and stability. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to cGMP guidelines for the manufacture of pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.