Description

Hyaluronidase, Ovine is a purified enzyme preparation derived from ovine (sheep) testes, identified by CAS No. 488712-31-8. This enzyme is critical for its ability to hydrolyze hyaluronic acid, a key component of the extracellular matrix, thereby increasing tissue permeability and facilitating the diffusion and absorption of other injected substances. It is an essential biopharmaceutical ingredient primarily required by manufacturers in the pharmaceutical, biotechnology, and research sectors for formulating injectable drugs, enhancing local anesthesia, and improving the efficacy of subcutaneous fluid administration.

Application

• Pharmaceutical Adjuvant: Used as a spreading agent to enhance the dispersion and absorption of co-administered drugs, such as local anesthetics, antibiotics, and contrast media.
• Ophthalmic Surgery: Facilitates the spread of local anesthetics in procedures like cataract surgery and is used in the management of vitreous hemorrhage.
• Subcutaneous Fluid Administration (Hypodermoclysis): Increases the absorption rate of large volumes of fluids administered subcutaneously, particularly in pediatric and geriatric care.
• Diagnostic Agent Enhancement: Improves the diffusion of diagnostic dyes and radiopaque substances for more accurate imaging.
• Research & Development: Utilized in biochemical and cell biology research to study glycosaminoglycan degradation, tissue permeability, and extracellular matrix dynamics.
• Dermatology and Aesthetics: Investigated for use in improving the diffusion of dermal fillers or reducing complications related to hyaluronic acid-based fillers.

Basic Information

Product Name	Hyaluronidase, Ovine
CAS No.	488712-31-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Hyaluronoglucosaminidase; Hyaluronate 4-glycanohydrolase; Spreading factor; Wydase; Alidase; Hyazyme; Ovine Testicular Hyaluronidase; OVH; OTH; Hyaluronidase from sheep testes; Hyaluronidase (ovine); CAS 37326-33-3 (for the enzyme class)
EINECS	Contact for details

Quality Control

Our Hyaluronidase, Ovine is manufactured and tested to meet stringent quality standards suitable for pharmaceutical applications. Each batch undergoes rigorous analytical testing, including activity assay, protein content determination, and purity profiling. Certificates of Analysis (COA) are provided, detailing specifications for potency, sterility (where applicable), endotoxin levels, and absence of specific impurities. Production can be aligned with cGMP guidelines upon request to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated. Keep container tightly sealed in a dry environment to prevent loss of enzymatic activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms
Assay (Enzymatic Activity)	≥ 300 USP units/mg (or as per grade)
Protein Content (Lowry)	Reported on COA
Purity (SDS-PAGE)	≥ 90%
pH (in solution)	6.0 - 7.5
Loss on Drying	≤ 5.0 %
Bacterial Endotoxins	< 1.0 EU/Unit (for injectable grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.