Description

(2S)-n-Boc-cis-4-Bromo-L-Proline T-Butyl Ester is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block for the construction of complex molecules, offering precise stereochemical control. It is primarily required by pharmaceutical R&D and fine chemical manufacturers for applications in peptide chemistry and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce a modified proline residue with a reactive bromine handle for further functionalization.
• Chemical Biology Research: Employed in the development of peptide-based probes, inhibitors, and tools for studying biological processes.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring specific, protected bromo-proline derivatives.

Basic Information

Product Name	(2S)-n-Boc-cis-4-Bromo-L-Proline T-Butyl Ester
CAS No.	487048-27-1
Molecular Formula	C14H24BrNO4
Molecular Weight	350.25 g/mol
Synonyms	1-(1,1-Dimethylethyl) (2S,4R)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-bromo-1,2-pyrrolidinedicarboxylate; (2S,4R)-1-(tert-Butyl) 2-methyl 4-bromopyrrolidine-1,2-dicarboxylate (Boc-protected); tert-Butyl (2S,4R)-4-bromo-2-[(tert-butoxycarbonyl)amino]pyrrolidine-1-carboxylate; Boc-4-Br-L-Pro-OtBu; cis-4-Bromo-N-Boc-L-proline tert-butyl ester; (2S,4R)-4-Bromo-N-Boc-proline tert-butyl ester; 4-Bromo-L-proline derivative, Boc-protected; L-Proline, 4-bromo-, 1,1-dimethylethyl ester, N-[(1,1-dimethylethoxy)carbonyl]-, (2S,4R)-
EINECS	Contact for details

Quality Control

Our (2S)-n-Boc-cis-4-Bromo-L-Proline T-Butyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Specific Rotation [α]D20	Contact for details
Purity (by HPLC Area %)	≥99.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.