Description

1-(4-Bromophenyl)Cyclobutanecarbonitrile is a versatile brominated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring a cyclobutane ring fused to a para-brominated benzonitrile moiety, makes it a critical intermediate for constructing complex pharmacophores and functional materials. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, where the bromophenyl and nitrile groups contribute to biological activity.
• Ligand and Catalyst Development: Acts as a starting material for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers due to its rigid, conjugated structure.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological processes and protein interactions.
• Scalable Process Chemistry: Suitable for use in kilo-lab and pilot plant scale-up for route scouting and optimization of candidate molecules.

Basic Information

Product Name	1-(4-Bromophenyl)Cyclobutanecarbonitrile
CAS No.	485828-58-8
Molecular Formula	C11H10BrN
Molecular Weight	236.11 g/mol
Synonyms	4-(Cyclobutane-1-carbonitrile-1-yl)bromobenzene; 1-(4-Bromophenyl)cyclobutanecarbonitrile; p-Bromophenyl cyclobutanecarbonitrile; 4-Bromophenyl cyclobutanecarbonitrile; Cyclobutanecarbonitrile, 1-(4-bromophenyl)-; 1-(p-Bromophenyl)cyclobutanecarbonitrile; (4-Bromophenyl)cyclobutanecarbonitrile
EINECS	Contact for details

Quality Control

Our 1-(4-Bromophenyl)Cyclobutanecarbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.