Description

Benzeneacetonitrile, 2-Fluoro-α-Hydroxy-, (Alphas)- (9Ci) is a specialized chiral fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the precise introduction of both fluorine and hydroxyl functional groups adjacent to a nitrile moiety on a benzene ring, enabling the construction of complex, biologically active molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its specific stereochemistry and fluorine atom are critical for modulating potency, metabolic stability, and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new Active Pharmaceutical Ingredients (APIs), particularly in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorine atom enhances lipophilicity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Fluorine Chemistry Research: An essential material for academic and industrial research exploring the effects of fluorination on molecular properties and reactivity.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fluorinated fine chemicals and specialty materials.

Basic Information

Item	Details
Product Name	Benzeneacetonitrile, 2-Fluoro-α-Hydroxy-, (Alphas)- (9Ci)
CAS No.	485759-27-1
Molecular Formula	C9H8FNO
Molecular Weight	165.16 g/mol
Synonyms	(αS)-α-Hydroxy-2-fluorobenzeneacetonitrile; (S)-2-Fluoro-2-hydroxy-2-phenylacetonitrile; (S)-α-Hydroxy-2-fluorophenylacetonitrile; 2-Fluoro-α-hydroxybenzeneacetonitrile, (S)-; (S)-2-Fluoro mandelonitrile; Fluorinated mandelonitrile derivative; (S)-Ofloxacin intermediate precursor
EINECS	Contact for details

Quality Control

Our Benzeneacetonitrile, 2-Fluoro-α-Hydroxy-, (Alphas)- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.