Description

(2S,4R)-1-Boc-2-Cyano-4-Hydroxypyrrolidine is a high-purity, chiral pyrrolidine derivative serving as a critical building block in modern organic synthesis. This compound matters for its role as a key intermediate in the production of complex pharmaceutical molecules, particularly protease inhibitors and other bioactive compounds. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of drug candidates, particularly those targeting viral proteases (e.g., HCV, HIV) and other enzymatic pathways.
• Peptidomimetics & Constrained Peptides: Used to introduce a rigid, functionalized pyrrolidine scaffold that mimics peptide turn structures, enhancing metabolic stability and binding affinity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the development of novel chiral ligands and organocatalysts used in enantioselective transformations.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and molecular tools for studying enzyme function and mechanism.
• Agrochemical Research: Utilized as a sophisticated intermediate in the development of new, high-specificity pesticides and herbicides.
• Academic & Contract Research: A valuable reagent for methodological development in academic laboratories and for custom synthesis projects in CROs and CDMOs.

Basic Information

Product Name	(2S,4R)-1-Boc-2-Cyano-4-Hydroxypyrrolidine
CAS No.	483366-12-7
Molecular Formula	C10H16N2O3
Molecular Weight	212.25 g/mol
Synonyms	1-Boc-2-Cyano-4-Hydroxypyrrolidine, (2S,4R)-; (4R)-1-[(1,1-Dimethylethoxy)carbonyl]-4-hydroxy-2-pyrrolidinecarbonitrile; tert-Butyl (4R)-4-hydroxy-2-cyanopyrrolidine-1-carboxylate; (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-pyrrolidinecarbonitrile; Boc-4-Hydroxy-2-cyanopyrrolidine; (2S,4R)-N-Boc-4-Hydroxy-2-cyanopyrrolidine; 1-Boc-4-hydroxy-2-cyanopyrrolidine
EINECS	Contact for details

Quality Control

Our (2S,4R)-1-Boc-2-Cyano-4-Hydroxypyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and IR spectroscopy. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.