Description

Benzonitrile, 5-Amino-2-(3-Oxo-4-Morpholinyl)- is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzonitrile and morpholinone functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and fine chemicals, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical producers focused on innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in kinase inhibitor and other targeted therapy research.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its reactive amino and carbonyl groups.
• Fine Chemical Synthesis: Serves as a precursor for the production of more complex heterocyclic compounds and specialty chemicals.
• Contract Manufacturing: Supplied to CMOs and CDMOs for the scale-up and commercial production of proprietary APIs.
• Biochemical Research: Potential use as a reagent or probe in biochemical assays and diagnostic development.
• Agrochemical Intermediates: Can be utilized in the research and development of new crop protection agents.

Basic Information

Product Name	Benzonitrile, 5-Amino-2-(3-Oxo-4-Morpholinyl)-
CAS No.	482308-11-2
Molecular Formula	C11H11N3O2
Molecular Weight	217.22 g/mol
Synonyms	5-Amino-2-(3-oxo-4-morpholinyl)benzonitrile; 2-Amino-5-cyanophenyl morpholin-3-one; 4-(3-Amino-4-cyanophenyl)morpholin-3-one; 5-Cyano-2-aminophenyl morpholin-3-one; 3-Morpholinone, 4-(3-amino-4-cyanophenyl)-; Benzonitrile, 5-amino-2-(3-oxo-4-morpholinyl)- (9CI); 482308-11-2
EINECS	Contact for details

Quality Control

Our production of Benzonitrile, 5-Amino-2-(3-Oxo-4-Morpholinyl)- adheres to stringent quality management systems to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. All materials are subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting full compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent oxidation and moisture uptake. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.