Description

Cefalotin is a first-generation cephalosporin antibiotic belonging to the β-lactam class. This compound is valued for its broad-spectrum bactericidal activity against a range of Gram-positive and some Gram-negative bacteria. It is a critical active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for the formulation of injectable antibiotic preparations. Cefalotin CAS NO 481649-28-9 is essential for producing medications used in hospital and clinical settings.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable formulations for systemic antibiotic therapy.
• Hospital Infection Treatment: Formulated for treating serious infections such as pneumonia, septicemia, and skin/soft tissue infections caused by susceptible organisms.
• Surgical Prophylaxis: Used in pre- and post-operative care to prevent surgical site infections.
• Bacterial Susceptibility Testing: Serves as a reference standard in microbiological laboratories for antibiotic susceptibility testing (AST).
• Veterinary Medicine: Employed in certain veterinary pharmaceutical products for treating bacterial infections in animals.
• Research & Development: Utilized in biochemical and pharmacological research to study β-lactam antibiotics and bacterial resistance mechanisms.

Basic Information

Product Name	Cefalotin
CAS No.	481649-28-9
Molecular Formula	C16H16N2O6S2
Molecular Weight	396.44 g/mol
Synonyms	Cephalothin; (6R,7R)-3-[(Acetyloxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-(2-Thienylacetamido)cephalosporanic acid; Cefalotin Sodium; Keflin; Ceporacin; Cephalothin Sodium; SQ 15871
EINECS	Contact for details

Quality Control

Our Cefalotin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use, including specifications for identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting compliance with relevant pharmacopeial standards (such as USP/EP) are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions with low humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Bacterial Endotoxins	< 0.20 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.