Description

3,3,3-Trifluoro-(2-Tetrahydrothienylmethyl)Propionic Acid is a high-value fluorinated organic acid building block featuring a unique heterocyclic structure. This compound is critical for introducing the trifluoromethyl group and sulfur-containing motifs into advanced molecular architectures, significantly altering physicochemical properties. It is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent for creating specialty polymers with tailored surface properties and chemical resistance.
• Ligand and Catalyst Development: The tetrahydrothiophene moiety makes it a valuable precursor for constructing chiral ligands used in asymmetric catalysis.
• Fluorine Chemistry Research: An essential building block in academic and industrial laboratories exploring new fluorination methodologies and organofluorine compounds.
• Peptide Mimetics: Incorporated into peptide analogs to enhance metabolic stability and membrane permeability for therapeutic applications.

Basic Information

Product Name	3,3,3-Trifluoro-(2-Tetrahydrothienylmethyl)Propionic Acid
CAS No.	480438-83-3
Molecular Formula	C8H9F3O2S
Molecular Weight	226.21 g/mol
Synonyms	3,3,3-Trifluoro-2-(tetrahydrothiophen-2-ylmethyl)propanoic acid; 2-[(Tetrahydro-2-thienyl)methyl]-3,3,3-trifluoropropionic Acid; 3,3,3-Trifluoro-2-(thiolan-2-ylmethyl)propionic Acid; 3,3,3-Trifluoro-2-(tetrahydro-2-thienylmethyl)propanoic Acid; 480438-83-3; TF-THMPA; Trifluoromethyl tetrahydrothiophene propionic acid
EINECS	Contact for details

Quality Control

Our production of 3,3,3-Trifluoro-(2-Tetrahydrothienylmethyl)Propionic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the exacting standards required for GMP-grade intermediates and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.