Description

3,3,3-Trifluoro-(2-Tetrahydrofuranylmethyl)Propionic Acid is a high-value fluorinated organic acid building block. This compound is essential for introducing the trifluoromethyl group and a tetrahydrofuran moiety into complex molecular architectures, significantly altering physicochemical properties. It is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs for enhanced metabolic stability, bioavailability, and lipophilicity.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group is a critical functional group for activity.
• Liquid Crystal & OLED Material Precursor: Serves as a specialized intermediate in the production of fluorinated compounds for electronic and display applications.
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, potentially improving chemical resistance, surface properties, and thermal stability.
• Organic Synthesis Reagent: A versatile reagent in academic and industrial R&D for constructing complex, fluorinated organic molecules via esterification, amidation, or other coupling reactions.

Basic Information

Product Name	3,3,3-Trifluoro-(2-Tetrahydrofuranylmethyl)Propionic Acid
CAS No.	480438-81-1
Molecular Formula	C8H11F3O3
Molecular Weight	212.17 g/mol
Synonyms	3,3,3-Trifluoro-2-(tetrahydrofuran-2-ylmethyl)propanoic acid; 2-(Tetrahydrofuran-2-ylmethyl)-3,3,3-trifluoropropionic Acid; 3,3,3-Trifluoro-2-((tetrahydro-2-furanyl)methyl)propanoic Acid; 480438-81-1; TFTHMPA; Trifluoromethyl tetrahydrofuran propionic acid
EINECS	Contact for details

Quality Control

Our production of 3,3,3-Trifluoro-(2-Tetrahydrofuranylmethyl)Propionic Acid adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques including HPLC, GC, and NMR to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting cGMP and ISO standards for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases, oxidizers, and incompatible materials. Due to its acidic nature, containers should be kept tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.