Description

2 3-Difluoro-4-Formyphenylboronic Acid CAS NO 480424-84-8 is a high-value, multi-functional boronic acid derivative characterized by its difluoro-substituted aromatic ring and formyl group. This compound is a critical advanced pharmaceutical intermediate and cross-coupling reagent in modern synthetic chemistry, enabling the construction of complex molecules with high precision. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the synthesis of active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for creating biaryl structures, which are core scaffolds in many drug candidates and organic electronic materials.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a precursor for developing novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: The formyl group allows for further functionalization to create novel ligands for catalysis or metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and polymers with specific optical or electronic properties.
• Chemical Biology Probes: Useful for synthesizing molecules that can interact with biological targets for diagnostic or research purposes.

Basic Information

Product Name	2,3-Difluoro-4-Formyphenylboronic Acid
CAS No.	480424-84-8
Molecular Formula	C7H5BF2O3
Molecular Weight	185.92 g/mol
Synonyms	(2,3-Difluoro-4-formylphenyl)boronic acid; 4-Borono-2,3-difluorobenzaldehyde; 2,3-Difluoro-4-formylbenzeneboronic acid; 2,3-Difluorobenzaldehyde-4-boronic acid; Boronic acid, B-(2,3-difluoro-4-formylphenyl)-; 480424-84-8; 2,3-Difluoro-4-carboxaldehydephenylboronic acid
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-Formyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.