Description

2-(3,5-Difluorophenyl)Ethenyl]Boronic Acid is a specialized organoboron compound featuring a difluorinated phenyl ring conjugated to a vinylboronic acid group. This structure is highly valuable as a key synthetic intermediate in modern cross-coupling reactions, enabling the precise construction of complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS research.
• Agrochemical Synthesis: Used to create advanced active ingredients with improved efficacy and environmental profiles.
• Material Science Research: Serves as a monomer or precursor in the development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Ligand and Catalyst Development: Used to construct complex ligand frameworks for asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and scale-up projects.

Basic Information

Product Name	2-(3,5-Difluorophenyl)Ethenyl]Boronic Acid
CAS No.	480424-67-7
Molecular Formula	C8H7BF2O2
Molecular Weight	183.95 g/mol
Synonyms	2-(3,5-Difluorophenyl)vinylboronic acid; (2-(3,5-Difluorophenyl)ethenyl)boronic acid; 3,5-Difluorostyrylboronic Acid; B-[2-(3,5-Difluorophenyl)ethenyl]boronic acid; 480424-67-7; (E)-2-(3,5-Difluorophenyl)vinylboronic acid; (Z)-2-(3,5-Difluorophenyl)vinylboronic acid (mixture of isomers)
EINECS	Contact for details

Quality Control

Our 2-(3,5-Difluorophenyl)Ethenyl]Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance in sensitive coupling reactions. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles against our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon/nitrogen) for long-term stability and to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.