Description

(11Bs)-8,9,10,11,12,13,14,15-Octahydro-N,n-Bis[(1R)-1-Phenylethyl]-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Amine is a sophisticated chiral phosphine-amine ligand, a key building block in advanced asymmetric synthesis. Its value lies in enabling highly selective catalytic transformations, crucial for producing enantiomerically pure intermediates in pharmaceutical and fine chemical manufacturing. This compound is essential for R&D chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where precise stereochemical control is a critical success factor.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for transition metal-catalyzed reactions, including hydrogenation, cross-coupling, and hydroformylation.
• Pharmaceutical Intermediate Synthesis: For the stereoselective construction of complex molecular architectures in API development.
• Agrochemical Research: In the synthesis of chiral active ingredients for herbicides, fungicides, and insecticides.
• Material Science: As a precursor or modifier for chiral polymers and advanced functional materials.
• Academic & Industrial R&D: A valuable tool for methodology development in organic and organometallic chemistry.
• Process Chemistry Optimization: For scaling up enantioselective synthetic routes from laboratory to pilot plant and commercial production.

Basic Information

Product Name	(11Bs)-8,9,10,11,12,13,14,15-Octahydro-N,n-Bis[(1R)-1-Phenylethyl]-Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Amine
CAS No.	479413-76-8
Molecular Formula	C38H38NO2P
Molecular Weight	571.69 g/mol
Synonyms	(11bS)-4-Amino-8,9,10,11,12,13,14,15-octahydro-N,N-bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine; (S)-4-Amino-8,9,10,11,12,13,14,15-octahydro-N,N-bis[(R)-1-phenylethyl]dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine; Chiral BINOL-Derived Phosphine-Amine Ligand; (S)-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine, 8,9,10,11,12,13,14,15-octahydro-N,N-bis[(1R)-1-phenylethyl]-, (11bS)-; CAS 479413-76-8
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management to ensure exceptional purity and enantiomeric excess, which are critical for catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity (HPLC/Chiral HPLC), and specific analytical data. Our quality systems support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; containers should be kept sealed under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.