Description

2-Pyrrolidineacetonitrile,1-Methyl-5-Thioxo-,(2R)-(9Ci) is a high-value, stereochemically defined chiral intermediate of significant interest in advanced organic synthesis. Its precise (2R) configuration and unique thioxo-pyrrolidineacetonitrile scaffold make it a critical building block for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets and enzyme inhibitors.
• Agrochemical Synthesis: Used in the development of novel, stereoselective pesticides and herbicides where specific chirality can influence biological activity and environmental profile.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing specialized chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: The pyrrolidine core is valuable for constructing peptidomimetic compounds in drug discovery programs.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds or probes for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high-purity, enantiomerically enriched intermediates.

Basic Information

Product Name	2-Pyrrolidineacetonitrile,1-Methyl-5-Thioxo-,(2R)-(9Ci)
CAS No.	479411-65-9
Molecular Formula	C7H10N2S
Molecular Weight	154.23 g/mol
Synonyms	(2R)-1-Methyl-5-thioxopyrrolidine-2-acetonitrile; (R)-1-Methyl-5-thioxopyrrolidine-2-acetonitrile; 1-Methyl-5-thioxopyrrolidine-2-acetonitrile, (2R)-; 2-Pyrrolidineacetonitrile, 1-methyl-5-thioxo-, (2R)-; (R)-1-Methyl-2-(cyanomethyl)-5-thioxopyrrolidine; (2R)-1-Methyl-5-thioxo-2-pyrrolidineacetonitrile
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems. Each batch is characterized and tested to ensure identity, purity, and enantiomeric excess meet the high standards required for research and development. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing key parameters such as assay (HPLC), chiral purity, and residual solvents. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.