Description

2-Pyrrolidineacetonitrile,1-Methyl-5-Thioxo-,(2S)-(9Ci) is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial interest. This compound matters for its role in the synthesis of complex molecules, particularly in medicinal chemistry where its specific stereochemistry is critical for biological activity. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for developing novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals. Its precise structure makes it a valuable synthon for targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs), particularly for neurological and metabolic targets.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Asymmetric Synthesis: Serves as a precursor for catalysts or ligands used in stereoselective chemical transformations.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals beyond pharmaceuticals.
• Bioconjugation Chemistry: Potential use in creating labeled compounds or probes for biochemical research due to its reactive nitrile and thioxo groups.

Basic Information

Product Name	2-Pyrrolidineacetonitrile,1-Methyl-5-Thioxo-,(2S)-(9Ci)
CAS No.	479411-61-5
Molecular Formula	C7H10N2OS
Molecular Weight	170.23 g/mol
Synonyms	(2S)-1-Methyl-5-thioxopyrrolidine-2-acetonitrile; (S)-1-Methyl-5-thioxopyrrolidine-2-acetonitrile; 1-Methyl-5-thioxopyrrolidine-2-acetonitrile, (2S)-; 2-Pyrrolidineacetonitrile, 1-methyl-5-thioxo-, (2S)-; (S)-2-(1-Methyl-5-thioxopyrrolidin-2-yl)acetonitrile; 479411-61-5; (2S)-1-Methyl-2,5-dihydro-1H-pyrrole-2-acetonitrile, 5-thioxo-
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidineacetonitrile,1-Methyl-5-Thioxo-,(2S)-(9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the stringent requirements of pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.