Description

L-Proline, 4-Methoxy-, Methyl Ester, (4R)- (9Ci) is a chiral, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis. This high-purity building block is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is essential for chemists and researchers in the life sciences sector who require enantiomerically pure intermediates for the synthesis of peptides, peptidomimetics, and other bioactive compounds. The compound is supplied under strict quality control to ensure batch-to-batch consistency for critical applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and metabolic disease research.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce constrained proline analogs, influencing peptide secondary structure and stability.
• Asymmetric Catalysis: Serves as a precursor or ligand in the development of chiral catalysts for stereoselective transformations.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of modified proline residues on drug potency and selectivity.
• Bioconjugation: Useful in the design and synthesis of chemically modified peptides for diagnostic and therapeutic applications.
• Academic & Industrial R&D: A valuable reagent for synthetic methodology development and exploring new chemical space in high-throughput screening libraries.

Basic Information

Item	Detail
Product Name	L-Proline, 4-Methoxy-, Methyl Ester, (4R)- (9Ci)
CAS No.	479234-88-3
Molecular Formula	C8H15NO3
Molecular Weight	173.21 g/mol
Synonyms	(4R)-4-Methoxy-L-proline methyl ester; Methyl (4R)-4-methoxy-L-prolinate; L-Proline, 4-methoxy-, methyl ester, (4R)-; (2S,4R)-1-Methyl 2-pyrrolidinecarboxylate, 4-methoxy-; 4-Methoxy-L-proline methyl ester; (4R)-4-Methoxypyrrolidine-2-carboxylic acid methyl ester; (2S,4R)-4-Methoxypyrrolidine-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Methoxy-, Methyl Ester, (4R)- (9Ci) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity, and residual solvent levels is provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.