Description

Hydromorphone 3-Sulfate is a specific sulfate ester derivative of the potent opioid analgesic, hydromorphone. This compound is of significant interest in pharmaceutical research and development, particularly for studying metabolic pathways and developing novel drug delivery systems. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical and fine chemical sectors who require high-purity, well-characterized chemical entities.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control testing of related pharmaceutical products.
• Metabolic Pathway Research: Acts as a key intermediate or marker in studies investigating the metabolism and biotransformation of hydromorphone and related opioids.
• Medicinal Chemistry Intermediate: Serves as a building block for the synthesis of novel opioid analogs or prodrugs in drug discovery programs.
• Forensic and Clinical Toxicology: Employed as a calibrant or control in analytical assays for detecting and quantifying opioid metabolites in biological samples.
• Impurity Profiling: Used to identify and quantify related substances in active pharmaceutical ingredient (API) batches of hydromorphone.

Basic Information

Product Name	Hydromorphone 3-Sulfate
CAS No.	479081-35-1
Molecular Formula	C17H19NO6S
Molecular Weight	365.40 g/mol
Synonyms	Dihydromorphinone 3-sulfate; 4,5α-Epoxy-3-hydroxy-17-methylmorphinan-6-one 3-sulfate; Hydromorphone sulfate ester; 3-O-Sulfohydromorphone; Hydromorphone 3-O-sulfate; 17-Methyl-4,5α-epoxy-3-hydroxy-morphinan-6-one 3-sulfate
EINECS	Contact for details

Quality Control

Our Hydromorphone 3-Sulfate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of residual solvents and moisture content. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.