Description

Desmethyl Thiosildenafil is a synthetic organic compound belonging to the thioanalogue class of PDE-5 inhibitors. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the study of erectile dysfunction therapeutics and related cardiovascular pathways. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in advanced API synthesis and novel drug discovery.

Application

• Pharmaceutical Intermediate: Key building block in the research and development of novel PDE-5 inhibitor compounds.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Biochemical Research: Employed in enzymatic studies to investigate phosphodiesterase inhibition mechanisms and selectivity.
• Metabolite Studies: Serves as a relevant compound for the synthesis and analysis of drug metabolites in pharmacokinetic research.
• Process Chemistry: Utilized in route scouting and optimization for the scalable synthesis of complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Desmethyl Thiosildenafil
CAS No.	479073-86-4
Molecular Formula	C21H27N7O3S2
Molecular Weight	489.62 g/mol
Synonyms	Thiosildenafil Impurity; Desmethyl Thio-Sildenafil; 5-[2-Ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; PDE-5 Inhibitor Thioanalogue; Sildenafil Thio Derivative; Research Compound 479073-86-4
EINECS	Contact for details

Quality Control

Our Desmethyl Thiosildenafil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets stringent research-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.