Description

1-[3,5-Bis(Trifluoromethyl)Phenyl]-3,3-Dimethyl-2-Azetanone is a high-value, specialized organic intermediate featuring a β-lactam (azetanone) core flanked by a highly electron-deficient aryl group. This compound matters for its role as a critical building block in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate the unique steric and electronic properties of the bis(trifluoromethyl)phenyl moiety into target compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and other enzyme-targeted therapies.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and fungicides, where the CF3 groups enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the development of organic electronic materials and polymers, where its structural motifs can influence electronic properties.
• Custom Synthesis & Contract Manufacturing: A vital substrate for fine chemical and CDMO (Contract Development and Manufacturing Organization) companies offering bespoke synthesis services.
• Academic Research: Used in university and institutional labs for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-[3,5-Bis(Trifluoromethyl)Phenyl]-3,3-Dimethyl-2-Azetanone
CAS No.	478261-83-5
Molecular Formula	C13H11F6NO
Molecular Weight	311.23 g/mol
Synonyms	3,3-Dimethyl-1-[3,5-bis(trifluoromethyl)phenyl]azetidin-2-one; 1-[3,5-Bis(trifluoromethyl)phenyl]-3,3-dimethylazetidin-2-one; 3,3-Dimethyl-1-(3,5-bis(trifluoromethyl)phenyl)-2-azetidinone; 2-Azetanone, 1-[3,5-bis(trifluoromethyl)phenyl]-3,3-dimethyl-; 3,3-Dimethyl-1-(α,α,α,α',α',α'-hexafluoro-m-tolyl)-2-azetidinone
EINECS	Contact for details

Quality Control

Our production of 1-[3,5-Bis(Trifluoromethyl)Phenyl]-3,3-Dimethyl-2-Azetanone adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.