Description

1H-Azepine, 1-(Chlorodifluoroacetyl)Hexahydro- (9Ci) is a high-value, specialized heterocyclic building block containing a reactive chlorodifluoroacetyl moiety. This compound is critical for advanced organic synthesis, particularly in the development of novel pharmaceuticals and agrochemicals where the introduction of a difluoromethyl group can significantly alter biological activity and metabolic stability. It serves as a key intermediate for research chemists and process development scientists in the fine chemical, pharmaceutical R&D, and crop protection industries seeking to incorporate fluorinated motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides where fluorination enhances efficacy and environmental profile.
• Material Science Precursor: Serves as a building block for specialty polymers and advanced materials with unique surface properties.
• Fluorination Chemistry: Employed in medicinal and synthetic chemistry to introduce the valuable -CF2- group via further functionalization.
• Academic & Contract Research: A valuable reagent for methodology development and exploration of new chemical space in university and CRO laboratories.
• Custom Synthesis: Used as a starting material for the contract manufacturing of complex, fluorinated target molecules.

Basic Information

Item	Detail
Product Name	1H-Azepine, 1-(Chlorodifluoroacetyl)Hexahydro- (9Ci)
CAS No.	478258-69-4
Molecular Formula	C8H12ClF2NO
Molecular Weight	211.64 g/mol
Synonyms	1-(Chlorodifluoroacetyl)hexahydro-1H-azepine; Hexahydro-1-(chlorodifluoroacetyl)-1H-azepine; N-(Chlorodifluoroacetyl)azepane; Azepane, 1-(chlorodifluoroacetyl)-; 1-Azepanecarbonyl chloride, 2,2-difluoro-; N-Chlorodifluoroacetylazepane
EINECS	Contact for details

Quality Control

Every batch of 1H-Azepine, 1-(Chlorodifluoroacetyl)Hexahydro- (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.