Description

Cefotaxime Sodium CAS NO 478250-23-6 is a broad-spectrum, third-generation cephalosporin antibiotic. It is a critical active pharmaceutical ingredient (API) valued for its efficacy against a wide range of Gram-positive and Gram-negative bacteria. This compound is essential for pharmaceutical manufacturers producing injectable antibiotic formulations for the treatment of serious infections in hospital and clinical settings.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable antibiotic formulations.
• Hospital Infection Treatment: Used in drugs targeting severe infections like meningitis, pneumonia, and septicemia.
• Surgical Prophylaxis: Incorporated into medications administered to prevent post-operative infections.
• Veterinary Medicine: Used in antibiotic preparations for treating bacterial infections in animals.
• Research & Development: Serves as a reference standard and key intermediate in antimicrobial research and new drug development.
• Bulk Drug Substance: Supplied to compounding pharmacies and large-scale pharmaceutical production facilities.

Basic Information

Product Name	Cefotaxime Sodium
CAS No.	478250-23-6
Molecular Formula	C16H16N5NaO7S2
Molecular Weight	477.44 g/mol
Synonyms	Cefotaxime Sodium Salt; (6R,7R)-3-(Acetoxymethyl)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Sodium; Sodium (6R,7R)-3-[(acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; Claforan (brand name); Cefotax; HR-756; RIT-3818; RU-24756
EINECS	Contact for details

Quality Control

Our Cefotaxime Sodium is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing parameters such as assay, related substances, residual solvents, and microbiological quality. We can supply material compliant with USP/EP/BP monograph specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	96.0% - 102.0% (on anhydrous basis)
pH (10% solution)	4.5 - 6.5
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C
Bacterial Endotoxins	< 0.10 EU/mg
Sterility (if required)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.