Description

(S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(3-Chloro-4-Hydroxyphenyl)Propanoic Acid is a high-purity, non-natural amino acid derivative featuring a chloro-tyrosine backbone protected with the Fmoc (9-fluorenylmethoxycarbonyl) group. This compound matters as a critical building block for solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a chlorinated phenolic side chain into complex peptide sequences. It is essential for researchers and manufacturers in pharmaceutical development and biochemical research who require specialized amino acids for creating novel peptide-based therapeutics, enzyme inhibitors, or diagnostic probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as a protected amino acid monomer for the automated or manual synthesis of custom peptides.
• Pharmaceutical Intermediates: Key raw material in the research and development of peptide drugs targeting various diseases.
• Bioconjugation & Probe Development: Used to introduce a reactive chlorophenol moiety into peptides for subsequent labeling or cross-linking applications.
• Enzyme Inhibitor Design: Serves as a core component in designing peptide-mimetic inhibitors for enzymes that recognize tyrosine or modified tyrosine residues.
• Chemical Biology Research: Employed in studying protein-protein interactions, signal transduction pathways, and post-translational modifications.
• Academic & Institutional R&D: Supplied to universities and research institutes for fundamental studies in medicinal chemistry and biochemistry.

Basic Information

Product Name	(S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(3-Chloro-4-Hydroxyphenyl)Propanoic Acid
CAS No.	478183-58-3
Molecular Formula	C24H20ClNO5
Molecular Weight	437.87 g/mol
Synonyms	Fmoc-3-chloro-L-tyrosine; Fmoc-3-Cl-Tyr-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-chloro-4-hydroxyphenyl)propanoic acid; N-α-Fmoc-3-chloro-L-tyrosine; Fmoc-L-3-chlorotyrosine; Fmoc-3-chlorotyrosine; N-Fmoc-3-chloro-L-tyrosine; 3-Chloro-L-tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our (S)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(3-Chloro-4-Hydroxyphenyl)Propanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.