Description

1,1,1-Trifluoro-3-Morpholino-2-Propanol is a high-value fluorinated morpholine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining a trifluoromethyl group with a morpholine moiety, makes it an essential intermediate for creating compounds with enhanced biological activity and physicochemical properties. This product is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atoms improve metabolic stability and membrane permeability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty chemicals with unique surface properties.
• Chemical Biology Probes: Useful for incorporating fluorine tags into molecules for studies using techniques like 19F NMR spectroscopy.

Basic Information

Product Name	1,1,1-Trifluoro-3-Morpholino-2-Propanol
CAS No.	478068-15-4
Molecular Formula	C7H10F3NO2
Molecular Weight	197.16 g/mol
Synonyms	3-Morpholino-1,1,1-trifluoropropan-2-ol; 1,1,1-Trifluoro-3-(morpholin-4-yl)-2-propanol; 2-Propanol, 1,1,1-trifluoro-3-(4-morpholinyl)-; 4-(2-Hydroxy-3,3,3-trifluoropropyl)morpholine; TFMP; Trifluoromorpholinopropanol
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-3-Morpholino-2-Propanol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.