Description

1,8-Naphthyridine-2-Acetonitrile,α-(3-Chlorophenyl)-5,7-Bis(Trifluoromethyl)-(9Ci) is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound matters for its unique structural features, combining a naphthyridine core with electron-withdrawing trifluoromethyl groups and a chlorophenyl acetonitrile moiety, which are critical for modulating the electronic and steric properties of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, particularly in the development of new drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly for targets requiring complex heterocyclic scaffolds with fluorine substitution.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science: Acts as a building block for creating advanced organic electronic materials, such as ligands for OLEDs or charge-transport materials.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D programs.
• Academic Research: A valuable reagent for universities and research institutes exploring new reactions, catalysis, and the properties of fluorinated heterocycles.

Basic Information

Product Name	1,8-Naphthyridine-2-Acetonitrile,α-(3-Chlorophenyl)-5,7-Bis(Trifluoromethyl)-(9Ci)
CAS No.	478043-30-0
Molecular Formula	C₁₉H₉ClF₆N₂
Molecular Weight	414.73 g/mol
Synonyms	α-(3-Chlorophenyl)-5,7-bis(trifluoromethyl)-1,8-naphthyridine-2-acetonitrile; 2-[2-(3-Chlorophenyl)-2-cyanoethyl]-5,7-bis(trifluoromethyl)-1,8-naphthyridine; 5,7-Bis(trifluoromethyl)-α-(3-chlorophenyl)-1,8-naphthyridine-2-acetonitrile; 1,8-Naphthyridine-2-acetonitrile, α-(3-chlorophenyl)-5,7-bis(trifluoromethyl)-; (3-Chlorophenyl)(5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl)acetonitrile; CAS 478043-30-0
EINECS	Contact for details

Quality Control

Our 1,8-Naphthyridine-2-Acetonitrile,α-(3-Chlorophenyl)-5,7-Bis(Trifluoromethyl)-(9Ci) is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.