Description

(2R)-3-[(4-Chlorophenyl)Sulfanyl]-1,1,1-Trifluoro-2-Propanol is a high-purity chiral organofluorine building block of significant interest in advanced synthetic chemistry. Its value lies in the unique combination of a chiral alcohol center, a sulfur-containing linker, and a trifluoromethyl group, enabling precise molecular modifications. This compound is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly where fluorine incorporation is desired to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in CNS and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty monomers or additives for advanced polymers with specific surface or optical properties.
• Fluorine Chemistry Studies: A valuable reference standard and building block in academic and industrial research focused on introducing fluorinated motifs into complex molecules.

Basic Information

Product Name	(2R)-3-[(4-Chlorophenyl)Sulfanyl]-1,1,1-Trifluoro-2-Propanol
CAS No.	477762-51-9
Molecular Formula	C9H8ClF3OS
Molecular Weight	256.67 g/mol
Synonyms	(R)-3-((4-Chlorophenyl)thio)-1,1,1-trifluoro-2-propanol; (2R)-3-[(4-Chlorophenyl)thio]-1,1,1-trifluoropropan-2-ol; (R)-1,1,1-Trifluoro-3-[(4-chlorophenyl)thio]-2-propanol; (R)-3-(p-Chlorophenylthio)-1,1,1-trifluoro-2-propanol; CAS 477762-51-9; Chiral Trifluoromethyl Sulfur Alcohol; 4-Chlorophenyl Trifluoromethyl Hydroxyethyl Sulfide (R-isomer)
EINECS	Contact for details

Quality Control

Our (2R)-3-[(4-Chlorophenyl)Sulfanyl]-1,1,1-Trifluoro-2-Propanol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its chemical nature as a fluoride/strong alkali reactive compound, keep away from incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.