Description

Bay 41-4109 (Less Active Enantiomer) is a specific stereoisomer of the heteroaryldihydropyrimidine (HAP) class, primarily utilized as a critical reference standard and a key intermediate in pharmaceutical research and development. This compound is of significant value for studying structure-activity relationships (SAR) and for use as a negative control in biological assays, helping to isolate the pharmacological effects of its more active counterpart. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on antiviral drug discovery, particularly for hepatitis B virus (HBV).

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control of active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a negative control in in vitro and in vivo studies to elucidate the specific mechanism of action of HAP compounds against HBV core protein assembly.
• Drug Discovery Intermediate: A crucial building block in the synthetic pathway for novel antiviral agents and for exploring enantiomer-specific therapeutic effects.
• Metabolite Studies: Employed in pharmacokinetic and metabolic profiling to understand the disposition and stability of the chiral drug molecule.
• Academic Research: Supports fundamental virology and medicinal chemistry research in academic and institutional laboratories.

Basic Information

Product Name	Bay 41-4109 (Less Active Enantiomer)
CAS No.	476617-51-3
Molecular Formula	C₂₁H₁₉ClN₄O₃
Molecular Weight	410.85 g/mol
Synonyms	4-Methyl-1-[2-(2-methylbenzamido)-4-(trifluoromethyl)phenyl]-1,4-dihydro-3,5-pyridinedicarboxylic acid dimethyl ester (Less Active Enantiomer); Bay 41-4109 Enantiomer; HAP-1 (Less Active Form); (S)-4-Methyl-1-[2-[(2-methylbenzoyl)amino]-4-(trifluoromethyl)phenyl]-1,4-dihydro-3,5-pyridinedicarboxylic acid dimethyl ester; 476617-51-3; Less Active Stereoisomer of Bay 41-4109; HBV Core Protein Allosteric Modulator (Inactive Enantiomer)
EINECS	Contact for details

Quality Control

Our Bay 41-4109 (Less Active Enantiomer) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure identity, potency, and the absence of the more active enantiomer. Certificates of Analysis (COA) detailing purity, chiral excess, and related substances are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (Less Active Enantiomer)
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.