Description

1-n-Boc-3-Cyanopyrrolidine is a versatile and high-purity chemical intermediate essential for modern organic synthesis. Its core value lies in its dual functionality, featuring a Boc-protected amine and a cyano group, which makes it a critical building block for constructing complex nitrogen-containing heterocycles. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of drug candidates, particularly those containing pyrrolidine scaffolds, such as protease inhibitors and kinase inhibitors.
• Peptide Mimetics & PROTACs: Used in the construction of peptidomimetics and Proteolysis Targeting Chimeras (PROTACs) due to its protected amine functionality.
• Agrochemical Synthesis: Serves as a precursor for developing novel herbicides and insecticides with specific biological activity.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Academic & Contract Research: Widely used in academic laboratories and CROs (Contract Research Organizations) for method development and exploratory synthesis.

Basic Information

Product Name	1-n-Boc-3-Cyanopyrrolidine
CAS No.	476493-40-0
Molecular Formula	C10H16N2O2
Molecular Weight	196.25 g/mol
Synonyms	1-Boc-3-cyanopyrrolidine; tert-Butyl 3-cyano-1-pyrrolidinecarboxylate; 3-Cyanopyrrolidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-cyanopyrrolidine; 3-Cyano-1-Boc-pyrrolidine; 1-N-Boc-3-cyanopyrrolidine; Pyrrolidine-1-carboxylic acid, 3-cyano-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1-n-Boc-3-Cyanopyrrolidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.