Description

D-Proline, 4-Fluoro-, Methyl Ester, (4R)-Rel- (9Ci) is a high-value, non-natural amino acid derivative featuring a fluorine atom at the 4-position of the proline ring and a methyl ester group. This compound is a critical chiral building block in modern pharmaceutical research and development, offering unique steric and electronic properties for drug design. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptide analogs and protease inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce fluorine for modulating metabolic stability, lipophilicity, and bioavailability of drug candidates.
• Asymmetric Synthesis: Serves as a chiral auxiliary or precursor in catalytic asymmetric reactions to construct complex molecular architectures.
• Peptidomimetic Development: Incorporated into peptidomimetic scaffolds to enhance proteolytic stability and receptor binding affinity.
• Chemical Biology Probes: Utilized in the development of labeled probes for studying enzyme mechanisms and protein-ligand interactions.
• Agrochemical Research: Potential intermediate in the development of novel, fluorinated bioactive compounds for crop protection.

Basic Information

Item	Detail
Product Name	D-Proline, 4-Fluoro-, Methyl Ester, (4R)-Rel- (9Ci)
CAS No.	475561-83-2
Molecular Formula	C7H10FNO2
Molecular Weight	159.16 g/mol
Synonyms	(4R)-4-Fluoro-D-proline methyl ester; Methyl (4R)-4-fluoro-D-prolinate; (R)-Methyl 4-fluoropyrrolidine-2-carboxylate; 4-Fluoro-D-proline methyl ester; D-4-Fluoroproline methyl ester; (4R)-4-Fluoroproline methyl ester; (R)-4-Fluoroproline methyl ester; 475561-83-2
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Fluoro-, Methyl Ester, (4R)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for advanced research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.