Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Dodecanylamine) is a synthetic, amine-functionalized phospholipid derivative, a key building block in advanced lipid-based formulations. Its unique structure, featuring a dodecylamine head group, provides enhanced stability and specific binding properties for creating targeted delivery systems. This high-purity lipid is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation therapeutics and diagnostic agents.

Application

• Lipid Nanoparticle (LNP) Formulation: A critical cationic/ionizable lipid component for the encapsulation and delivery of nucleic acids (mRNA, siRNA, pDNA) in therapeutic and vaccine applications.
• Liposome & Niosome Production: Used to engineer stable, functionalized vesicles for targeted drug delivery, with the amine group facilitating surface modification and ligand conjugation.
• Gene Therapy Vectors: Serves as a structural element in non-viral transfection reagents and complexes to enhance cellular uptake and endosomal escape.
• Bioconjugation & Surface Chemistry: The primary amine group acts as a handle for covalent attachment of targeting moieties (e.g., antibodies, peptides) or fluorescent probes.
• Biomimetic Membrane Research: Employed in model membrane studies to investigate membrane-protein interactions and cellular signaling processes.
• Diagnostic Agent Development: Incorporated into contrast agents or assay components for medical imaging and in vitro diagnostics.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Dodecanylamine)
CAS No.	474944-10-0
Molecular Formula	C71H137N2O8P
Molecular Weight	1153.88 g/mol
Synonyms	DOPE-N-dodecylamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-dodecyl; N-Dodecyl-DOPE; DODAC-DOPE analog; DLin-DOPE-N-C12; C12-DOPE; Amine-functionalized DOPE; Phospholipid conjugate C12; N-(Dodecyl)-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Dodecanylamine) is manufactured under strict quality management systems. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and consistency, meeting the rigorous standards required for pharmaceutical and life science research. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and critical physical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The product is hygroscopic and moisture-sensitive; allow the sealed vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (IR & NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (Total Lipids)	≥ 98.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%
Peroxide Value	≤ 3.0 meq/kg
Primary Amine Content	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.