Description

1,2-Dioleoyl-Sn-Glycero-3-Phospho(Ethylene Glycol) (Sodium Salt) is a synthetic, anionic phospholipid-PEG conjugate, widely recognized as a key functional lipid in advanced formulation science. Its primary value lies in its ability to impart stealth properties and enhance colloidal stability in aqueous systems, which is critical for improving the performance and longevity of lipid-based delivery vehicles. This high-purity material is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, consistent components for cutting-edge applications.

Application

• Lipid Nanoparticle (LNP) Formulation: A critical component for constructing stable, PEGylated lipid bilayers in mRNA and siRNA delivery systems.
• Liposome & Niosome Stabilization: Used to create sterically stabilized ("stealth") liposomes, reducing opsonization and extending circulation time for drug delivery.
• Biomimetic Membrane Research: Serves as a model lipid for studying membrane fluidity, fusion, and surface functionalization in biophysical research.
• Diagnostic Agent Carrier: Employed in the development of contrast agents and diagnostic probes requiring long blood residence times.
• Surface Modification & Coatings: Utilized to create biocompatible, protein-resistant coatings on nanoparticles and medical devices.
• Cosmetic & Dermal Delivery Systems: Incorporated into advanced cosmetic formulations for the stable encapsulation and targeted delivery of active ingredients.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phospho(Ethylene Glycol) (Sodium Salt)
CAS No.	474923-51-8
Molecular Formula	C45H84NaO10P
Molecular Weight	839.11 g/mol
Synonyms	18:1 PEG2000 PE; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (sodium salt); DSPE-PEG(2000); DSPE-mPEG 2000; PEG2000-DSPE; mPEG2000-DSPE; Poly(ethylene glycol) (2000) derivatized phosphatidylethanolamine; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (common trade name variant)
EINECS	Contact for details

Quality Control

Every batch of our 1,2-Dioleoyl-Sn-Glycero-3-Phospho(Ethylene Glycol) (Sodium Salt) is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for pharmaceutical and life science research. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, documenting critical parameters such as purity, fatty acid composition, and functional integrity. Our commitment to quality supports compliance with cGMP guidelines for advanced therapeutic medicinal product (ATMP) development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C ± 5°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
PEG Molecular Weight (NMR)	2000 ± 10%
Oleoyl Content (GC)	≥ 85% of total fatty acids
Phospholipid Content	≥ 80%
Solvents (Residual)	Meets ICH guidelines
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.